Automated cellular instance segmentation is a process utilized for accelerating biological research for the past two decades, and recent advancements have produced higher quality results with less effort from the biologist. Most current endeavors focus on completely cutting the researcher out of the picture by generating highly generalized models. However, these models invariably fail when faced with novel data, distributed differently than the ones used for training. Rather than approaching the problem with methods that presume the availability of large amounts of target data and computing power for retraining, in this work we address the even greater challenge of designing an approach that requires minimal amounts of new annotated data as well as training time. We do so by designing specialized contrastive losses that leverage the few annotated samples very efficiently. A large set of results show that 3 to 5 annotations lead to models with accuracy that: 1) significantly mitigate the covariate shift effects; 2) matches or surpasses other adaptation methods; 3) even approaches methods that have been fully retrained on the target distribution. The adaptation training is only a few minutes, paving a path towards a balance between model performance, computing requirements and expert-level annotation needs.

The pandemic of these very recent years has led to a dramatic increase in people wearing protective masks in public venues. This poses obvious challenges to the pervasive use of face recognition technology that now is suffering a decline in performance. One way to address the problem is to revert to face recovery methods as a preprocessing step. Current approaches to face reconstruction and manipulation leverage the ability to model the face manifold, but tend to be generic. We introduce a method that is specific for the recovery of the face image from an image of the same individual wearing a mask. We do so by designing a specialized GAN inversion method, based on an appropriate set of losses for learning an unmasking encoder. With extensive experiments, we show that the approach is effective at unmasking face images. In addition, we also show that the identity information is preserved sufficiently well to improve face verification performance based on several face recognition benchmark datasets.

Person re-identification is a challenging task because of the high intra-class variance induced by the unrestricted nuisance factors of variations such as pose, illumination, viewpoint, background, and sensor noise. Recent approaches postulate that powerful architectures have the capacity to learn feature representations invariant to nuisance factors, by training them with losses that minimize intra-class variance and maximize inter-class separation, without modeling nuisance factors explicitly. The dominant approaches use either a discriminative loss with margin, like the softmax loss with the additive angular margin, or a metric learning loss, like the triplet loss with batch hard mining of triplets. Since the softmax imposes feature normalization, it limits the gradient flow supervising the feature embedding. We address this by joining the losses and leveraging the triplet loss as a proxy for the missing gradients. We further improve invariance to nuisance factors by adding the discriminative task of predicting attributes. Our extensive evaluation highlights that when only a holistic representation is learned, we consistently outperform the state-of-the-art on the three most challenging datasets. Such representations are easier to deploy in practical systems. Finally, we found that joining the losses removes the requirement for having a margin in the softmax loss while increasing performance.

The study of signatures of aging in terms of genomic biomarkers can be uniquely helpful in understanding the mechanisms of aging and developing models to accurately predict the age. Prior studies have employed gene expression and DNA methylation data aiming at accurate prediction of age. In this line, we propose a new framework for human age estimation using information from human dermal fibroblast gene expression data. First, we propose a new spatial representation as well as a data augmentation approach for gene expression data. Next in order to predict the age, we design an architecture of neural network and apply it to this new representation of the original and augmented data, as an ensemble classification approach. Our experimental results suggest the superiority of the proposed framework over state-of-the-art age estimation methods using DNA methylation and gene expression data.

This work provides a unified framework for addressing the problem of visual supervised domain adaptation and generalization with deep models. The main idea is to exploit the Siamese architecture to learn an embedding subspace that is discriminative, and where mapped visual domains are semantically aligned and yet maximally separated. The supervised setting becomes attractive especially when only few target data samples need to be labeled. In this scenario, alignment and separation of semantic probability distributions is difficult because of the lack of data. We found that by reverting to point-wise surrogates of distribution distances and similarities provides an effective solution. In addition, the approach has a high "speed" of adaptation, which requires an extremely low number of labeled target training samples, even one per category can be effective. The approach is extended to domain generalization. For both applications the experiments show very promising results.

Detecting anomalous data within time series is a very relevant task in pattern recognition and machine learning, with many possible applications that range from disease prevention in medicine, e.g., detecting early alterations of the health status before it can clearly be defined as "illness" up to monitoring industrial plants. Regarding this latter application, detecting anomalies in an industrial plant's status firstly prevents serious damages that would require a long interruption of the production process. Secondly, it permits optimal scheduling of maintenance interventions by limiting them to urgent situations. At the same time, they typically follow a fixed prudential schedule according to which components are substituted well before the end of their expected lifetime. This paper describes a case study regarding the monitoring of the status of Laser-guided Vehicles (LGVs) batteries, on which we worked as our contribution to project SUPER (Supercomputing Unified Platform, Emilia Romagna) aimed at establishing and demonstrating a regional High-Performance Computing platform that is going to represent the main Italian supercomputing environment for both computing power and data volume.